General Information

    • DRAMP ID

    • DRAMP21202

    • Peptide Name

    • HPA3NT3-analog (Derived from HPA3NT3)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKKLKKLFKKILKLK

    • Sequence Length

    • 15

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.19642077] Gram-positive bacteria : Staphylococcus aureus(MIC=8 μM), Bacillus subtilis(MIC=8 μM), Listeria monocytogenes(MIC=4 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=8 μM), Salmonella typhimurium(MIC=1 μM), Pseudomonas aeruginosa(MIC=2 μM);
      • Fungi : Candida albicans(MIC=4-8 μM), Trichosporon beigelli(MIC=1 μM)

    • Hemolytic Activity

      • [Ref.19642077] 0% hemolysis at 100 μM , 3% hemolysis at 200 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21202 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21202.

Physicochemical Information

    • Formula

    • C96H171N23O16

    • Absent Amino Acids

    • ACDEGHMNPQRSTVWY

    • Common Amino Acids

    • K

    • Mass

    • 1903.56

    • PI

    • 10.85

    • Basic Residues

    • 8

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +8

    • Boman Index

    • -1384

    • Hydrophobicity

    • -0.393

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21202

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Trichosporon beigelli

Literature Information

  • ·Literature 1

    • Title

    • Effect of Leucine and Lysine substitution on the antimicrobial activity and evaluation of the mechanism of the HPA3NT3 analog peptide.

    • Reference

    • J Pept Sci. 2009 Sep;15(9):589-94. doi: 10.1002/psc.1155.

    • Author

    • Gopal R, Park SC, Ha KJ, Cho SJ, Kim SW, Song PI, Nah JW, Park Y, Hahm KS