General Information

    • DRAMP ID

    • DRAMP21206

    • Peptide Name

    • AmyI-1-18 (D15R) (Derived from AmyI-1-18)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HLNKRVQRELIGWLRWLK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=11±1 μM).
      • [Ref.26850838] Fungi: Candida albicans(IC50=31±4 μM)

    • Hemolytic Activity

      • [Ref.27478151] 2% hemolysis at 50 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21206 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21206.

Physicochemical Information

    • Formula

    • C109H177N35O23

    • Absent Amino Acids

    • ACDFMPSTY

    • Common Amino Acids

    • L

    • Mass

    • 2345.82

    • PI

    • 11.72

    • Basic Residues

    • 6

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +5

    • Boman Index

    • -4527

    • Hydrophobicity

    • -0.739

    • Aliphatic Index

    • 124.44

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 647.06

    • Polar Residues

    • 2

DRAMP21206

DRAMP21206 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-21 and its amino acid-substituted analogs.

    • Reference

    • J Biosci Bioeng. 2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.

    • Author

    • Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T
  • ·Literature 2

    • Title

    • Effect of alanine, leucine, and arginine substitution on antimicrobial activity against candida albicans and action mechanism of a cationic octadecapeptide derived from α-amylase of rice.

    • Reference

    • Biopolymers. 2016 Mar;106(2):219-229. doi: 10.1002/bip.22820.

    • Author