General Information

    • DRAMP ID

    • DRAMP21211

    • Peptide Name

    • AmyI-1-18 (N3L, G12R) (Derived from AmyI-1-18)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • HLLKRVQRELIRWLDWLK

    • Sequence Length

    • 18

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.27478151] Gram-negative bacteria : Porphyromonas gingivalis(IC50=2.9±0.2 μM)

    • Hemolytic Activity

      • [Ref.27478151] 14% hemolysis at 50 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21211 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21211.

Physicochemical Information

    • Formula

    • C113H184N34O24

    • Absent Amino Acids

    • ACFGMNPSTY

    • Common Amino Acids

    • L

    • Mass

    • 2402.92

    • PI

    • 10.9

    • Basic Residues

    • 6

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +4

    • Boman Index

    • -4337

    • Hydrophobicity

    • -0.506

    • Aliphatic Index

    • 146.11

    • Half Life

      • Mammalian:3.5 hour
      • Yeast:10 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 647.06

    • Polar Residues

    • 0

DRAMP21211

DRAMP21211 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antimicrobial activity against Porphyromonas gingivalis and mechanism of action of the cationic octadecapeptide AmyI-1-18 and its amino acid-substituted analogs.

    • Reference

    • J Biosci Bioeng. 2016 Dec;122(6):652-659. doi: 10.1016/j.jbiosc.2016.05.008.

    • Author

    • Taniguchi M, Ochiai A, Takahashi K, Nakamichi SI, Nomoto T, Saitoh E, Kato T, Tanaka T