• • DRAMP ID

  • DRAMP21233

• • Peptide Name

  • R2PLx-22 (Derived from R2PLx)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GIMDTVKNAAKNLAGQLLDKLK

• • Sequence Length

  • 22

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.30279210] Gram-positive bacteria : Staphylococcus aureus(NCTC 10788)(MIC=256 μM, MBC=256 μM), MRSA (ATCC 12493)(MIC>512 μM, MBC>512 μM), Enterococcus faecalis(NCTC 12697)(MIC>512 μM, MBC>512 μM);
    • Gram-negative bacteria : Escherichia coli(NCTC 10418)(MIC=128 μM, MBC=256 μM), Pseudomonas aeruginosa(ATCC 27853)(MIC= μM, MBC= μM);
    • Fungi : Candida albicans(NCTC 1467)(MIC=512 μM, MBC>512 μM)

• • Hemolytic Activity

  • • [Ref.30279210] 3% hemolysis at 1 μM , 4% hemolysis at 2 μM , 1% hemolysis at 4 μM , 0% hemolysis at 8 μM , 2% hemolysis at 16 μM , 0% hemolysis at 32 μM , 0% hemolysis at 128 μM , 3% hemolysis at 256 μM , 13% hemolysis at 512 μM against human red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Random coil, alpha helix

• • Structure Description

  • The CD spectra of both peptides shows the pattern of random coil in aqueous solution and a typical α-helix CD spectra in 50% of TFE solution.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21233.

DRAMP21233

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

• ·Literature 1

• • Title

  • A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells.

• • Pubmed ID

  • 30279210

• • Reference

  • Biosci Rep. 2018 Nov 9;38(6). pii: BSR20180710. doi: 10.1042/BSR20180710.

• • Author

  • Chen X, Zhang L, Ma C, Zhang Y, Xi X, Wang L, Zhou M, Burrows JF, Chen T