• • DRAMP ID

  • DRAMP21242

• • Peptide Name

  • Epinecidin-8 (Derived from Epinecidin)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • FIFHIIKGLFHAGKMI

• • Sequence Length

  • 16

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.23598079] Gram-positive bacteria : Staphylococcus aureus(MIC=6.25 mg/L), Staphylococcus sp.(MIC=12.5 mg/L);
    • Gram-negative bacteria : Grouper Vibrio alginolyticus(MIC=12.5 mg/L), Vibrio harveyi(MIC=6.25 mg/L)

• • Hemolytic Activity

  • • [Ref.23598079] 0% hemolysis at 50 mg/L , 10% hemolysis at 100 mg/L , 20% hemolysis at 200 mg/L , 50% hemolysis at 400 mg/L against sheep red blood cells

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21242.

DRAMP21242

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

• ·Literature 1

• • Title

  • Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus.

• • Pubmed ID

  • 23598079

• • Reference

  • Peptides. 2013 Jun;44:139-48. doi: 10.1016/j.peptides.2013.04.004.

• • Author

  • Lin MC, Hui CF, Chen JY, Wu JL