General Information

    • DRAMP ID

    • DRAMP21244

    • Peptide Name

    • TsAP-S1 (Derived from TsAP-1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLSLIPKLVKKIIKAFK

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.23770440] Gram-positive bacteria : Staphylococcus aureus(MIC=2.5 μM, MBC=20 μM);
      • Gram-negative bacteria : Escherichia coli(MIC=5 μM, MBC=20 μM);
      • Fungi : Candida albicans(MIC=2.5 μM, MBC=5 μM)

    • Hemolytic Activity

      • [Ref.23770440] 30% hemolysis at 5 μM , 85% hemolysis at 10 μM , 100% hemolysis at 20 μM against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21244 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21244.

Physicochemical Information

    • Formula

    • C100H172N22O19

    • Absent Amino Acids

    • CDEGHMNQRTWY

    • Common Amino Acids

    • K

    • Mass

    • 1986.6

    • PI

    • 10.6

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +5

    • Boman Index

    • 1018

    • Hydrophobicity

    • 0.859

    • Aliphatic Index

    • 160.59

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP21244

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans, Anticancer against H157, H838, MCF-7, PC3 and U251-MG

Literature Information

  • ·Literature 1

    • Title

    • Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities.

    • Reference

    • Biochimie. 2013 Sep;95(9):1784-94. doi: 10.1016/j.biochi.2013.06.003.

    • Author

    • Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T, Shaw C