General Information

    • DRAMP ID

    • DRAMP21249

    • Peptide Name

    • PVP (Derived from MP-B and MP-VT1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKWRKLLKWLAKK

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.27591703] Gram-positive bacteria : Staphylococcus aureus isolates(MIC=4.3 ± 3.5 mg/L, MBC=6.0 ± 3.5 mg/L), Enterococcus faecalis isolates(MIC=2.7 ± 1.2 mg/L, MBC=3.3 ± 1.2 mg/L);
      • Gram-negative bacteria : Pseudomonas aeruginosa isolates(MIC=1.3 ± 0.6 mg/L, MBC=1.7 ± 0.6 mg/L), Acinetobacter baumannii isolates(MIC=2.3 ± 1.5 mg/L, MBC=2.7 ± 1.2 mg/L)

    • Hemolytic Activity

      • [Ref.27591703] 0% hemolysis at 64 μg/ml against human red blood cells; 0% hemolysis at 64 μg/ml against sheep red blood cells

    • Cytotoxicity

      • [Ref.27591703] The cell viability of HEK293 cells induced by PV is 98.8%, 100%, 97.3%, 94.2%, 92.3%, 89.2% and 84.6% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 μg/mL within 24h.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21249 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21249.

Physicochemical Information

    • Formula

    • C85H144N24O14

    • Absent Amino Acids

    • CDEFGHIMNPQSTVY

    • Common Amino Acids

    • K

    • Mass

    • 1726.23

    • PI

    • 11.43

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +7

    • Boman Index

    • -2699

    • Hydrophobicity

    • -1.269

    • Aliphatic Index

    • 97.69

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 916.67

    • Polar Residues

    • 0

DRAMP21249

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Design and characterization of short hybrid antimicrobial peptides from pEM-2, mastoparan-VT1, and mastoparan-B.

    • Reference

    • Chem Biol Drug Des. 2017 Mar;89(3):327-338. doi: 10.1111/cbdd.12864.

    • Author

    • Memariani H, Shahbazzadeh D, Ranjbar R, Behdani M, Memariani M, Pooshang Bagheri K