General Information

    • DRAMP ID

    • DRAMP21251

    • Peptide Name

    • AaeAP1 (Scorpionida, Arachricla, Arthropoda)

    • Source

    • Androctonus aeneas

    • Family

    • Not found

    • Gene

    • AP1

    • Sequence

    • FLFSLIPSVIAGLVSAIRN

    • Sequence Length

    • 19

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal

    • Target Organism

      • [Ref.25626077] Gram-positive bacteria : Staphylococcus aureus(MIC=16 mg/L, MBC=32 mg/L);
      • Gram-negative bacteria : Escherichia coli(MIC>512 mg/L);
      • Fungi : Candida albicans(MIC=32 mg/L, MBC=64 mg/L)

    • Hemolytic Activity

      • [Ref.25626077] 100% hemolysis at 16 μg/ml against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21251 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21251.

Physicochemical Information

    • Formula

    • C96H157N23O24

    • Absent Amino Acids

    • CDEHKMQTWY

    • Common Amino Acids

    • ILS

    • Mass

    • 2017.44

    • PI

    • 9.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +1

    • Boman Index

    • 1636

    • Hydrophobicity

    • 1.584

    • Aliphatic Index

    • 164.21

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP21251

DRAMP21251 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities.

    • Reference

    • Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.

    • Author

    • Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C