General Information
-
DRAMP ID
- DRAMP21251
-
Peptide Name
- AaeAP1 (Scorpionida, Arachricla, Arthropoda)
-
Source
- Androctonus aeneas
-
Family
- Not found
-
Gene
- AP1
-
Sequence
- FLFSLIPSVIAGLVSAIRN
-
Sequence Length
- 19
-
UniProt Entry
- A0A060QQ43
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
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Target Organism
-
- [Ref.25626077] Gram-positive bacteria : Staphylococcus aureus(MIC=16 mg/L, MBC=32 mg/L);
- Gram-negative bacteria : Escherichia coli(MIC>512 mg/L);
- Fungi : Candida albicans(MIC=32 mg/L, MBC=64 mg/L)
-
Hemolytic Activity
-
- [Ref.25626077] 100% hemolysis at 16 μg/ml against horse red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21251.
Physicochemical Information
-
Formula
- C96H157N23O24
Absent Amino Acids
- CDEHKMQTWY
Common Amino Acids
- ILS
Mass
- 2017.44
PI
- 9.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 12
Net Charge
- +1
-
Boman Index
- 1636
Hydrophobicity
- 1.584
Aliphatic Index
- 164.21
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP21251
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria. Antifungal activity against Candida albicans
Literature Information
- ·Literature 1
-
Title
- AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities.
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Pubmed ID
- 25626077
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Reference
- Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.
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Author
- Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C