General Information

    • DRAMP ID

    • DRAMP21253

    • Peptide Name

    • AaeAP1a (Derived from AaeAP1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLFKLIPKAIKGLVKAIRK

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.25626077] Gram-positive bacteria : Staphylococcus aureus(MIC=4 mg/L, MBC=32 mg/L);
      • Gram-negative bacteria : Escherichia coli(MIC=16 mg/L, MBC=32 mg/L);
      • Fungi : Candida albicans(MIC=4 mg/L, MBC=16 mg/L)

    • Hemolytic Activity

      • [Ref.25626077] 100% hemolysis at 32 μg/ml against horse red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21253 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21253.

Physicochemical Information

    • Formula

    • C108H187N27O20

    • Absent Amino Acids

    • CDEHMNQSTWY

    • Common Amino Acids

    • K

    • Mass

    • 2183.84

    • PI

    • 11.39

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • 141

    • Hydrophobicity

    • 0.647

    • Aliphatic Index

    • 148.95

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP21253

DRAMP21253 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans

Literature Information

  • ·Literature 1

    • Title

    • AaeAP1 and AaeAP2: novel antimicrobial peptides from the venom of the scorpion, Androctonus aeneas: structural characterisation, molecular cloning of biosynthetic precursor-encoding cDNAs and engineering of analogues with enhanced antimicrobial and anticancer activities.

    • Reference

    • Toxins (Basel). 2015 Jan 23;7(2):219-37. doi: 10.3390/toxins7020219.

    • Author

    • Du Q, Hou X, Wang L, Zhang Y, Xi X, Wang H, Zhou M, Duan J, Wei M, Chen T, Shaw C