General Information

    • DRAMP ID

    • DRAMP21255

    • Peptide Name

    • WL1 (Derived from CP-1)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • WLSKTAKKL

    • Sequence Length

    • 9

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 μM), Staphylococcus aureus ATCC 43300(MIC>128 μM), Staphylococcus epidermidis ATCC 12228(MIC>128 μM), Bacillus subtilis CMCC 63501(MIC>128 μM);
      • Gram-negative bacteria : Escherichia coli ATCC25922(MIC>128 μM), Escherichia coli UB1005(MIC>128 μM), Pseudomonas aeruginosa ATCC 27853(MIC>128 μM), Salmonella typhimurium ATCC 7731(MIC>128 μM), Salmonella pullorum C79-13(MIC>128 μM)

    • Hemolytic Activity

      • [Ref.29266746] MHC5>128 μM against human red blood cells

    • Cytotoxicity

      • [Ref.29266746] The cell viability of IPEC-J2 cells induced by WL1 is 99.2%, 89.8%, 86.2%, 90.8%, 87.8%, 94.3% and 76.5% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 μM. The cell viability of IPEC-J2 cells induced by the control Melittin is 7

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Unordered conformation

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21255 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21255.

Physicochemical Information

    • Formula

    • C51H87N13O12

    • Absent Amino Acids

    • CDEFGHIMNPQRVY

    • Common Amino Acids

    • K

    • Mass

    • 1074.33

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +3

    • Boman Index

    • -864

    • Hydrophobicity

    • -0.522

    • Aliphatic Index

    • 97.78

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 687.5

    • Polar Residues

    • 2

DRAMP21255

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.

    • Reference

    • Chem Biol Drug Des. 2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.

    • Author

    • Dong N, Wang Z, Chou S, Zhang L, Shan A, Jiang J