• • DRAMP ID

  • DRAMP21258

• • Peptide Name

  • Cecropin P1 (CP-1) (nematodes, animals)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • SWLSKTAKKLENSAKKRISEGIAIAIQGGPR

• • Sequence Length

  • 31

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.29266746] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 μM), Staphylococcus aureus ATCC 43300(MIC>128 μM), Staphylococcus epidermidis ATCC 12228(MIC>128 μM), Bacillus subtilis CMCC 63501(MIC=1 μM);
    • Gram-negative bacteria : Escherichia coli ATCC25922(MIC=0.5 μM), Escherichia coli UB1005(MIC=0.5 μM), Pseudomonas aeruginosa ATCC 27853(MIC>128 μM), Salmonella typhimurium ATCC 7731(MIC=2 μM), Salmonella pullorum C79-13(MIC=0.5 μM)

• • Hemolytic Activity

  • • [Ref.29266746] MHC5>128 μM against human red blood cells

• • Cytotoxicity

  • • [Ref.29266746] The cell viability of IPEC-J2 cells induced by CP-1 is 87.9%, 100.4%, 93.5%, 88.5%, 91.8%, 84.2% and 86.3% at peptide concentrations of 2, 4, 8, 16, 32, 64 and 128 μM. The cell viability of IPEC-J2 cells induced by the control Melittin is

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • 2N92 resolved by NMR

• Predicted Structure

• There is no predicted structure for DRAMP21258.

DRAMP21258

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

• ·Literature 1

• • Title

  • Antibacterial activities and molecular mechanism of amino-terminal fragments from pig nematode antimicrobial peptide CP-1.

• • Pubmed ID

  • 29266746

• • Reference

  • Chem Biol Drug Des. 2018 May;91(5):1017-1029. doi: 10.1111/cbdd.13165.

• • Author

  • Dong N, Wang Z, Chou S, Zhang L, Shan A, Jiang J