General Information

    • DRAMP ID

    • DRAMP21261

    • Peptide Name

    • KL4A6 (De novo synthesis)

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • LLKAAAKAAAKLL

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.26385363] Gram-positive bacteria : Staphylococcus aureus ATCC 29213(MIC>128 μM), Staphylococcus epidermidis ATCC 12228(MIC=128 μM), Streptococcus faecalis ATCC 29212(MIC=16 μM), Bacillus subtilis CMCC 63501(MIC=32 μM);
      • Gram-negative bacteria : Escherichia coli ATCC25922(MIC=2 μM), Escherichia coli K88(MIC=32 μM), Escherichia coli CVCC 1515(MIC=32 μM), Escherichia coli UB1005(MIC=32 μM), Bacterium pyocyaneum ATCC 27853(MIC>128 μM), Salmonella typhimurium ATCC 14028(MIC=128 μM), Salmonella pullorum C79–13(MIC>128 μM)

    • Hemolytic Activity

      • [Ref.26385363] MHC5>256 μM against human red blood cells

    • Cytotoxicity

      • [Ref.26385363] The cell viability of HEK293 cells induced by KL4A6 is 107.8%, 108.3%, 104.4%, 104.7%, 105.6%, 100%, 94.4% and 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM. The cell viability of HEK293 cells induced by control Meli

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21261 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21261.

Physicochemical Information

    • Formula

    • C60H112N16O14

    • Absent Amino Acids

    • CDEFGHIMNPQRSTVWY

    • Common Amino Acids

    • A

    • Mass

    • 1281.65

    • PI

    • 10.3

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +3

    • Boman Index

    • 1389

    • Hydrophobicity

    • 1.1

    • Aliphatic Index

    • 166.15

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP21261

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria

Literature Information

  • ·Literature 1

    • Title

    • Rational design of mirror-like peptides with alanine regulation.

    • Reference

    • Amino Acids. 2016 Feb;48(2):403-17. doi: 10.1007/s00726-015-2094-y.

    • Author

    • Li W, Tan T, Xu W, Xu L, Dong N, Ma D, Shan A