General Information
-
DRAMP ID
- DRAMP21277
-
Peptide Name
- LK-L8Q (Derived from LK)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- LKKLLKLQKKLLKLAG
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.23894079] Gram-positive bacteria : Staphylococcus aureus (ATCC 29213)(MIC>40 μM);
- Gram-negative bacteria : Escherichia coli (ATCC 25922)(MIC=2.5 μM)
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Hemolytic Activity
-
- [Ref.23894079] MHC10=320 μM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21277.
Physicochemical Information
-
Formula
- C88H167N23O18
Absent Amino Acids
- CDEFHIMNPRSTVWY
Common Amino Acids
- L
Mass
- 1835.44
PI
- 10.7
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +6
-
Boman Index
- -165
Hydrophobicity
- 0.069
Aliphatic Index
- 176.88
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP21277
Comments Information
Function
- Antibacterial activity against Gram-negative bacteria. Uncertain antibacterial activity against Gram-positive bacteria.
Literature Information
- ·Literature 1
-
Title
- Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides.
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Pubmed ID
- 23894079
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Reference
- ChemMedChem. 2013 Oct;8(10):1638-42. doi: 10.1002/cmdc.201300264.
-
Author
- Son M, Lee Y, Hwang H, Hyun S, Yu J