General Information

    • DRAMP ID

    • DRAMP21346

    • Peptide Name

    • [Tyr]12-VmCT1-NH2 (Derived from VmCT1)

    • Source

    • synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLGALWNVAKSYF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.31212183] Gram-positive bacteria: Micrococcus luteus A270 (MIC=0.8 μmol/L), Staphylococcus aureus ATCC 29213 (MIC=1.6 μmol/L), Bacillus megaterium ATCC 10778 (MIC=1.6 μmol/L), Bacillus subtilis ATCC 6633 (MIC=1.6 μmol/L);
      • Gram-negative bacteria: Escherichia coli SBS 363 (MIC=6.3 μmol/L)，Serratia marcescens ATCC 4112 (MIC=0.2 μmol/L);
      • Fungi: Candida albicans MDM8 (MIC=12.5 μmol/L), Candida tropicalis IOC 4560 (MIC=6.3 μmol/L)

    • Hemolytic Activity

      • [Ref.31212183] 25% hemolysis at 12.5 μmol/L, 60% hemolysis at 25 μmol/L, 85% hemolysis at 50 μmol/L, 100% hemolysis at 100 μmol/L for human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • 24% α-helix in 60% TFE/Water. ## 2%α-helix in water.

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21346 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21346.

Physicochemical Information

    • Formula

    • C76H106N16O17

    • Absent Amino Acids

    • CDEHIMPQRT

    • Common Amino Acids

    • AFL

    • Mass

    • 1515.77

    • PI

    • 8.59

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 1100

    • Hydrophobicity

    • 0.785

    • Aliphatic Index

    • 97.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 582.5

    • Polar Residues

    • 4

DRAMP21346

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria. Antifungal activity against Candida albicans and Candida tropicalis IOC 4568.

Literature Information

  • ·Literature 1

    • Title

    • Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens

    • Reference

    • Bioorg Chem. 2019 Jun 8;90:103038. doi: 10.1016/j.bioorg.2019.103038.

    • Author

    • Pedron CN, Araújo I, da Silva Junior PI, Dias da Silva F, Torres MT, Oliveira Junior VX