• • DRAMP ID

  • DRAMP21403

• • Peptide Name

  • peptide 1 (De Novo Synthesis)

• • Source

  • synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • ITEVITILLNRLTDRLEK

• • Sequence Length

  • 18

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.31117348] Gram-positive bacteria:Staphylococcus aureus ATCC 6538(MIC>100μM), Bacillus subtilis ATCC 6633(MIC>100μM);
    • Gram-negative bacteria:Escherichia coli ATCC 15597(MIC>100μM), Pseudomonas aeruginosa (MIC>100μM), Salmonella Typhimurium 6192(MIC>100μM), Klebsiella pneumoniae NCTC 5055(MIC>100μM)

• • Hemolytic Activity

  • • [Ref.31117348] 5% hemolysis at 250 μM against human blood cells.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • α-helix mainly in 10 mM phosphate buffer, pH7.4

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21403.

DRAMP21403

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.

• ·Literature 1

• • Title

  • Helminth Defense Molecules as Design Templates for Membrane Active Antibiotics.

• • Pubmed ID

  • 31117348

• • Reference

  • ACS Infect Dis. 2019 May 30. doi: 10.1021/acsinfecdis.9b00157.

• • Author

  • Hammond K, Lewis H, Faruqui N, Russell C, Hoogenboom BW, Ryadnov MG