• • DRAMP ID

  • DRAMP21405

• • Peptide Name

  • LGL13K (De Novo Synthesis)

• • Source

  • synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • GKIIKLKASLKLL

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.31071184] Gram-positive bacteria:Staphylococcus aureus Xen36(MIC=83.3μg/ml), Staphylococcus aureus USA300(Uknow);
    • Gram-negative bacteria: Pseudomonas aeruginosa (MIC=10.4μg/ml)

• • Hemolytic Activity

  • • [Ref.31071184] LD50=560μg/ml against human blood cells

• • Cytotoxicity

  • • [Ref.31071184] The cytotoxicity of L-GL13K on HEK cells is 2.1%, 3.3%, 2.4%, 1.2%24.3%, 51.7% and 73.6% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 μg/mL, while the cytotoxicity of PMX on HEK cells (Control samples) is 1.2%, 1.2%, 6.6%, 3.6%, 39.6%, 47.1% and 68.5% at peptide concentrations of 1, 3.9, 15.6, 62.5, 250 and 1000 μg/mL.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Unknown

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP21405.

DRAMP21405

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.

• ·Literature 1

• • Title

  • In vivo activity and low toxicity of the second-generation antimicrobial peptide DGL13K.

• • Pubmed ID

  • 31071184

• • Reference

  • PLoS One. 2019 May 9;14(5):e0216669. doi: 10.1371/journal.pone.0216669. eCollection 2019.

• • Author

  • Gorr SU, Flory CM, Schumacher RJ