General Information
-
DRAMP ID
- DRAMP21410
-
Peptide Name
- dBac4K (Derived from CAMPs)
-
Source
- synthetic construct
-
Family
- Not found
-
Gene
- Not found
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Sequence
- klckivvikvck
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Sequence Length
- 12
-
UniProt Entry
- No entry found
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Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC>64μM), Staphylococcus epidermidis (MIC=8-16μM), Bacillus subtilis (MIC>64μM), Enterococcus faecalis (MIC>64μM);
- Gram-negative bacteria: Escherichia coli (MIC=4-8μM), Salmonella typhimurium (MIC=32-64μM), Pseudomonas aeruginosa (MIC>64μM), Acinetobacter baumannii (MIC>64μM)
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Hemolytic Activity
-
- [Ref.31056261] 0.7% hemolysis at 100 μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
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N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Disulfide bond between Cys3 and Cys11.
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Stereochemistry
- D
-
Structure
- β-turn
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21410.
Physicochemical Information
-
Formula
- C63H120N16O13S2
Absent Amino Acids
- ADEFGHMNPQRSTWY
Common Amino Acids
- K
Mass
- 1373.87
PI
- 9.7
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +4
-
Boman Index
- 724
Hydrophobicity
- 1.233
Aliphatic Index
- 170
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 11.36
Polar Residues
- 2
DRAMP21410
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.
Literature Information
- ·Literature 1
-
Title
- A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.
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Pubmed ID
- 31056261
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Reference
- Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2
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Author
- Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI