General Information

    • DRAMP ID

    • DRAMP21412

    • Peptide Name

    • dBacK (Derived from CAMPs)

    • Source

    • synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • rkcrivvirvcr

    • Sequence Length

    • 12

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.31056261] Gram-positive bacteria: Staphylococcus aureus (MIC=4-8μM), Staphylococcus epidermidis (MIC=1-2μM), Bacillus subtilis (MIC=1-2μM), Enterococcus faecalis (MIC=4μM);
      • Gram-negative bacteria: Escherichia coli (MIC=1-2μM), Salmonella typhimurium (MIC=1-2μM), Pseudomonas aeruginosa (MIC=2-4μM), Acinetobacter baumannii (MIC=2-4μM)

    • Hemolytic Activity

      • [Ref.31056261] 0.6% hemolysis at 100 μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys3 and Cys11.

    • Stereochemistry

    • D

    • Structure

    • β-turn

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21412 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21412.

Physicochemical Information

    • Formula

    • C63H121N25O13S2

    • Absent Amino Acids

    • ADEFGHLMNPQSTWY

    • Common Amino Acids

    • R

    • Mass

    • 1500.93

    • PI

    • 11.54

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +5

    • Boman Index

    • -4071

    • Hydrophobicity

    • 0.392

    • Aliphatic Index

    • 137.5

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 11.36

    • Polar Residues

    • 2

DRAMP21412

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin.

    • Reference

    • Biochem Biophys Res Commun. 2019 Jun 25;514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2

    • Author

    • Sim JY, Kim S, Lee J, Lim H, Kim HH, Park ZY, Kim JI