General Information
-
DRAMP ID
- DRAMP21415
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Peptide Name
- α4-short (Derived from α4)
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Source
- synthetic construct
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Family
- Not found
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Gene
- Not found
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Sequence
- LKKWWKTSKGLLGGLLGKVTSVIK
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Sequence Length
- 24
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UniProt Entry
- No entry found
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Protein Existence
- Synthetic form
Activity Information
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Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.30967458] Gram-positive bacteria: Staphylococcus aureus 467-1 (MIC=2μM), Staphylococcus aureus 0154-17 (MIC=2μM), Staphylococcus aureus 187-10 (MIC=16μM), Staphylococcus aureus 0194-19 (MIC=2μM), Staphylococcus aureus US300 (MIC=8μM), Staphylococcus aureus 122-12 (MIC=2μM), Enterococcus faecium 23614 (MIC=1μM), Enterococcus faecium 14678 (MIC=1μM), Enterococcus faecium 26125 (MIC=1μM);
- Gram-negative bacteria:Pseudomonas aeruginosa 16-21 (MIC=2μM), Pseudomonas aeruginosa 16-72 (MIC=2μM), Pseudomonas aeruginosa 16-73 (MIC=2μM), Pseudomonas aeruginosa 0038-13 (MIC=2μM), Pseudomonas aeruginosa 0038-14 (MIC=1μM), Pseudomonas aeruginosa 0040-21 (MIC=2μM), Pseudomonas aeruginosa 0046-106 (MIC=8μM), Pseudomonas aeruginosa 0068-37 (MIC=16μM), Pseudomonas aeruginosa 0071-75 (MIC=2μM), Pseudomonas aeruginosa 97-5 (MIC=2μM), Pseudomonas aeruginosa 109-10 (MIC=2μM), Pseudomonas aeruginosa 16-21 (MIC=2μM)Pseudomonas aeruginosa 132-37 (MIC=2μM), Pseudomonas aeruginosa 129-5 (MIC=2μM), Pseudomonas aeruginosa 152-19 (MIC=2μM), Pseudomonas aeruginosa 159-30 (MIC=2μM), Pseudomonas aeruginosa 474-1 (MIC=2μM), Acinetobacter baumannii C3 (MIC=1μM), Acinetobacter baumannii D4 (MIC=2μM), Acinetobacter baumannii A2 (MIC=4μM), Escherichia coli YDC518 (MIC=1μM), Escherichia coli YDC575 (MIC=2μM), Escherichia coli YDC596 (MIC=1μM), Escherichia coli YDC107 (MIC=1μM), Escherichia coli YDC337 (MIC=1μM), Escherichia coli YDC748 (MIC=1μM), Klebsiella pneumoniae A2 (MIC=4μM), Klebsiella pneumoniae D4 (MIC=2μM), Klebsiella pneumoniae 438-16 (MIC=4μM)
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Hemolytic Activity
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- [Ref.30967458] 1% hemolysis at 17 μM, 2% hemolysis at 30 μM, 3% hemolysis at 63 μM against human red blood cells
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Cytotoxicity
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- [Ref.30967458] The white blood cell toxicity of α4-short is ~0%, ~0%, ~0%, ~0%, ~0%, 1.8% and 3.1% at peptide concentrations of 1, 2, 4, 8, 16, 32 and 64 μM.
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Free
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C-terminal Modification
- Free
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Nonterminal Modifications and Unusual Amino Acids
- None
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Stereochemistry
- L
-
Structure
- Unknown
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21415.
Physicochemical Information
-
Formula
- C126H214N32O29
Absent Amino Acids
- ACDEFHMNPQRY
Common Amino Acids
- K
Mass
- 2641.28
PI
- 10.7
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 10
Net Charge
- +6
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Boman Index
- 78
Hydrophobicity
- 0.088
Aliphatic Index
- 121.67
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 11000
Absorbance 280nm
- 478.26
Polar Residues
- 8
DRAMP21415
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.
Literature Information
- ·Literature 1
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Title
- Antibacterial Properties and Efficacy of a Novel SPLUNC1-Derived Antimicrobial Peptide, α6-Short, in a Murine Model of Respiratory Infection
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Pubmed ID
- 30967458
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Reference
- mBio. 2019 Mar-Apr; 10(2): e00226-19. Published online 2019 Apr 9. doi: 10.1128/mBio.00226-19
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Author
- Shasha Jiang, Berthony Deslouches, Chen Chen, Matthew E. Di, Y. Peter Di