• DRAMP ID

    • DRAMP21420
    • Peptide Name

    • AY1C (Derived from AY1)
    • Source

    • synthetic construct
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • FLPKLFAKITKKNMAHIRC
    • Sequence Length

    • 19
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • [Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=15μM), Escherichia coli (MIC=17μM), Salmonella typhi(MIC=15μM), Klebsiella pneumoniae(MIC=12μM)
    • Hemolytic Activity

      • [Ref.30872680] 4% hemolysis at 10 μM, 9% hemolysis at 50 μM, 8% hemolysis at 100μM against human red blood cells
    • Cytotoxicity

    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • N-terminal modification

    • C-terminal modification

    • Other modifications

    • Stereochemistry

    • Structure

    • Helix-loop-helix derived from NMR
    • Structure Description

    • N/A
    • PDB ID

    • 5YKL resolved by NMR
    • DRAMP21420 helical wheel diagram
    • Formula

    • C105H175N29O22S2
    • Absent Amino Acids

    • DEGQSVWY
    • Common Amino Acids

    • K
    • Mass

    • 2259.85
    • PI

    • 10.48
    • Basic Residues

    • 6
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • -1810
    • Hydrophobicity

    • 5.79
    • Aliphatic Index

    • 92.63
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP21420

DRAMP21420 chydropathy plot
    • Function

    • Antimicrobial activity against Gram-negative bacteria.
  • Literature 1
    • Reference

    • Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi: 10.1038/s41598-019-41005-7
    • Author

    • Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS
    • Title

    • A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria