General Information
-
DRAMP ID
- DRAMP21421
-
Peptide Name
- AY1C-AgNP (Derived from AY1)
-
Source
- synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- FLPKLFAKITKKNMAHIRC
-
Sequence Length
- 19
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
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Target Organism
-
- [Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=15μM), Escherichia coli (MIC=12μM), Salmonella typhi(MIC=15μM), Klebsiella pneumoniae(MIC=10μM)
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Hemolytic Activity
-
- [Ref.30872680] 4% hemolysis at 10 μM, 6% hemolysis at 50 μM, 9% hemolysis at 100μM against human red blood cells
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Conjugation with silver nanoparticles
-
Stereochemistry
- L
-
Structure
- Helix-loop-helix derived from NMR
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP21421.
Physicochemical Information
-
Formula
- C105H175N29O22S2
Absent Amino Acids
- DEGQSVWY
Common Amino Acids
- K
Mass
- 2259.85
PI
- 10.48
Basic Residues
- 6
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +6
-
Boman Index
- -1810
Hydrophobicity
- 0.058
Aliphatic Index
- 92.63
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP21421
Comments Information
Function
- Antibacterial activity against Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria
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Pubmed ID
- 30872680
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Reference
- Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi: 10.1038/s41598-019-41005-7
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Author
- Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS