General Information

    • DRAMP ID

    • DRAMP21422

    • Peptide Name

    • CAY1 (Derived from AY1)

    • Source

    • synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CFLPKLFAKITKKNMAHIR

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.30872680] Gram-negative bacteria:Pseudomonas aeruginosa (MIC=10μM), Escherichia coli (MIC=10μM), Salmonella typhi(MIC=Not know), Klebsiella pneumoniae(MIC=7μM)

    • Hemolytic Activity

      • [Ref.30872680] 4% hemolysis at 10 μM, 9% hemolysis at 50 μM, 10% hemolysis at 100μM against human red blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Helix-loop-helix derived from NMR

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP21422 helical wheel diagram

    • PDB ID

    • 5YKQ resolved by NMR

    • Predicted Structure

    • There is no predicted structure for DRAMP21422.

Physicochemical Information

    • Formula

    • C105H175N29O22S2

    • Absent Amino Acids

    • DEGQSVWY

    • Common Amino Acids

    • K

    • Mass

    • 2259.85

    • PI

    • 10.48

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +6

    • Boman Index

    • -1810

    • Hydrophobicity

    • 0.058

    • Aliphatic Index

    • 92.63

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP21422

DRAMP21422 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria

    • Reference

    • Sci Rep. 2019; 9: 4485. Published online 2019 Mar 14. doi: 10.1038/s41598-019-41005-7

    • Author

    • Pal I, Bhattacharyya D, Kar RK, Zarena D, Bhunia A, Atreya HS