General Information
-
DRAMP ID
- DRAMP21442
-
Peptide Name
- peptide 19 (Derived from B1)
-
Source
- synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- afalKKK
-
Sequence Length
- 7
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- [Ref.30842436] Gram-positive bacteria:MRSP C22963(MIC=16µg/ml), MSSA ATCC 29213(MIC=32µg/ml);
- Gram-negative bacteria:Pseudomonas aeruginosa(MIC>64µg/ml)
-
Hemolytic Activity
-
- [Ref.30842436] < 8% hemolysis at 150 µM against human red blood cells
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Residue 1 and residue 3 are 2-naphthylmethylglycine
-
Stereochemistry
- Mixed (D-Ala1, D-Phe2, D-Ala3, D-Leu4)
-
Structure
- Unknown
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP21442.
Physicochemical Information
-
Formula
- C39H68N10O8
Absent Amino Acids
- CDEGHIMNPQRSTVWY
Common Amino Acids
- K
Mass
- 805.03
PI
- 10.3
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 4
Net Charge
- +3
-
Boman Index
- -513
Hydrophobicity
- -0.214
Aliphatic Index
- 84.29
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP21442
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria. Antimicrobial activity against Gram-negative bacteria is uncertain.
Literature Information
- ·Literature 1
-
Title
- Characterization, mechanism of action and optimization of activity of a novel peptide-peptoid hybrid against bacterial pathogens involved in canine skin infections
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Pubmed ID
- 30842436
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Reference
- Sci Rep. 2019; 9: 3679. Published online 2019 Mar 6. doi: 10.1038/s41598-019-39042-3
-
Author
- Ines Greco, Agnete Plahn Emborg, Bimal Jana, Natalia Molchanova, Alberto Oddo, Peter Damborg, Luca Guardabassi, Paul R. Hansen