• DRAMP ID

    • DRAMP21465
    • Peptide Name

    • P1-Ll-1577 (De Novo Synthesis)
    • Source

    •  Leptodactylus latrans (Anura: Leptodactylidae)
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • DEMKLDGFNMHLE
    • Sequence Length

    • 13
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=40.5μM);
      • Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=20μM)
    • Hemolytic Activity

      • [Ref.30423858] 100% hemolysis MHC=640μM against human blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • Linear
    • N-terminal modification

    • Free
    • C-terminal modification

    • Amidation (Glu13)
    • Other modifications

    • None
    • Stereochemistry

    • L
    • Structure

    • Random coil predicted by PSIPRED and GOR V
    • Structure Description

    • P1-Ll-1577, although presenting contributions of turn structure, is less ordered in the presence of TFE (percentage of an unordered structure higher than 40%).
    • DRAMP21465 helical wheel diagram
    • Formula

    • C67H103N17O23S2
    • Absent Amino Acids

    • ACIPQRSTVWY
    • Common Amino Acids

    • DELM
    • Mass

    • 1578.77
    • PI

    • 4.31
    • Basic Residues

    • 2
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 3
    • Boman Index

    • -2945
    • Hydrophobicity

    • -83.08
    • Aliphatic Index

    • 60
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 2

DRAMP21465

    • Function

    • Antimicrobial activity against Gram-positive bacteria and Gram-nagetive bacteria.
  • Literature 1
    • Reference

    • Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943
    • Author

    • Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli
    • Title

    • Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides