• DRAMP ID

    • DRAMP21466
    • Peptide Name

    • P2-Ll-1298 (De Novo Synthesis)
    • Source

    •  Leptodactylus latrans (Anura: Leptodactylidae)
    • Family

    • N/A
    • Gene

    • N/A
    • Sequence

    • AAGKGLVSNLLEK
    • Sequence Length

    • 13
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • N/A
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=49μM);
      • Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=24.6μM)
    • Hemolytic Activity

      • [Ref.30423858] 100% hemolysis MHC=320μM against human blood cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • N/A
    • Linear/Cyclic/Branched

    • Linear
    • N-terminal modification

    • Free
    • C-terminal modification

    • Amidation (Lys13)
    • Other modifications

    • None
    • Stereochemistry

    • L
    • Structure

    • Helix(K4-E12) predicted by PSIPRED and helix(L6-L1
    • Structure Description

    • P2-Ll-1298 showed contributions of α-helix.
    • DRAMP21466 helical wheel diagram
    • Formula

    • C57H102N16O18
    • Absent Amino Acids

    • CDFHIMPQRTWY
    • Common Amino Acids

    • L
    • Mass

    • 1299.53
    • PI

    • 8.64
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 6
    • Boman Index

    • -365
    • Hydrophobicity

    • 21.54
    • Aliphatic Index

    • 127.69
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 4

DRAMP21466

    • Function

    • Antimicrobial activity against Gram-positive bacteria and Gram-nagetive bacteria.
  • Literature 1
    • Reference

    • Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943
    • Author

    • Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli
    • Title

    • Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides