General Information

    • DRAMP ID

    • DRAMP21466

    • Peptide Name

    • P2-Ll-1298 (De Novo Synthesis)

    • Source

    •  Leptodactylus latrans (Anura: Leptodactylidae)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • AAGKGLVSNLLEK

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=49μM);
      • Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=24.6μM)

    • Hemolytic Activity

      • [Ref.30423858] 100% hemolysis MHC=320μM against human blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Helix(K4-E12) predicted by PSIPRED and helix(L6-L10) predicted by GOR V

    • Structure Description

    • P2-Ll-1298 showed contributions of α-helix.

    • Helical Wheel Diagram

    • DRAMP21466 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21466.

Physicochemical Information

    • Formula

    • C57H102N16O18

    • Absent Amino Acids

    • CDFHIMPQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 1299.53

    • PI

    • 8.64

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • -365

    • Hydrophobicity

    • 0.215

    • Aliphatic Index

    • 127.69

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP21466

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides

    • Reference

    • Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943

    • Author

    • Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli