General Information

    • DRAMP ID

    • DRAMP21467

    • Peptide Name

    • P3-Ll-2085 (De Novo Synthesis)

    • Source

    •  Leptodactylus latrans (Anura: Leptodactylidae)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLLDFLKAAGKGLVSNLLEK

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.30423858] Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC=15μM);
      • Gram-negative bacteria:Escherichia coli ATCC 25922(MIC=15μM)

    • Hemolytic Activity

      • [Ref.30423858] 100% hemolysis MHC=40μM against human blood cells

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Helix(L2-E19) predicted by PSIPRED and Helix(L3-A9, L13-L17) predicted by GOR V

    • Structure Description

    • Deconvolution spectra by SELCON and CONTILL method indicated more than 70% helical structure for P3-Ll-2085

    • Helical Wheel Diagram

    • DRAMP21467 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21467.

Physicochemical Information

    • Formula

    • C96H164N24O27

    • Absent Amino Acids

    • CHIMPQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2086.5

    • PI

    • 8.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 76

    • Hydrophobicity

    • 0.46

    • Aliphatic Index

    • 141.5

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP21467

DRAMP21467 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria and Gram-nagetive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Leptodactylus latrans Amphibian Skin Secretions as a Novel Source for the Isolation of Antibacterial Peptides

    • Reference

    • Molecules. 2018 Nov; 23(11): 2943. Published online 2018 Nov 11. doi: 10.3390/molecules23112943

    • Author

    • Alvaro Siano, Maria Veronica Humpola, Eliandre de Oliveira, Fernando Albericio, Arturo C Simonetta, Rafael Lajmanovich, Georgina G Tonarelli