General Information

    • DRAMP ID

    • DRAMP21481

    • Peptide Name

    • 6K-F17

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • KKKKKKAAFAAWAAFAA

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • [Ref.29275987] Gram-negative bacteria: E. coli (MIC= 1.6 μM)

    • Hemolytic Activity

      • [Ref.29275987] MHC = 320 μM against human red blood cells. Note: Minimum hemolytic concentration (MHC) is the minimum peptide concentration at which red blood cells undergo > 2% hemolysis.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • ①Random coils in aqueous buffer. ②α-helix in SDS detergent micelles.

    • Structure Description

    • As previously reported, 6K-F17 adopts a random coil structure in aqueous buffer and an α helix in the presence of SDS detergent micelles.

    • Helical Wheel Diagram

    • DRAMP21481 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP21481.

Physicochemical Information

    • Formula

    • C₈₉H₁₄₂N₂₄O₁₈

    • Absent Amino Acids

    • CDEGHILMNPQRSTVY

    • Common Amino Acids

    • A

    • Mass

    • 1836.26

    • PI

    • 10.7

    • Basic Residues

    • 6

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +6

    • Boman Index

    • -1053

    • Hydrophobicity

    • -0.253

    • Aliphatic Index

    • 47.06

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:3 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 343.75

    • Polar Residues

    • 0

DRAMP21481

Comments Information

    • Function

    • Antibacterial activity against Gram-negative bacteria. No experiments about antibacterial activity against Gram-positive bacteria are recorded.

Literature Information

  • ·Literature 1

    • Title

    • Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides

    • Reference

    • Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020. Epub 2017 Oct 21.

    • Author

    • Tracy A Stone, Gregory B Cole, Huong Q Nguyen, Simon Sharpe, Charles M Deber