• • DRAMP ID

  • DRAMP28985

• • Peptide Name

  • peptide 1 (Derived from Mag2)

• • Source

  • Synthetic construct

• • Family

  • N/A

• • Gene

  • N/A

• • Sequence

  • GIKKFLKSXKKFVKXFK

• • Sequence Length

  • 17

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.33466998] Gram-positive bacteria: Staphylococcus aureus (MIC = 12.5 μM).
    • Gram-negative bacteria: Escherichia coli (MIC = 3.125 μM), Pseudomonas aeruginosa (MIC = 3.125 μM), multiple-drug resistant P.aeruginosa (MIC = 3.125 μM)

• • Hemolytic Activity

  • • [Ref.33466998] It has hemolysis against human red blood cells at 50 μM

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • The X (position: 9 and 15) in sequence indicate Aib residues (2-Aminoisobutyric acid)

• • Stereochemistry

  • L

• • Structure

  • α-helix in 20 mM PBS solution (pH = 7.4) with 1% SDS at peptide concentrations of 100 μM

• • Structure Description

  • No detailed structure description

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP28985.

DRAMP28985

• • Function

  • Antibacterial activity against Gram-positive and Gram-negative bacteria

• ·Literature 1

• • Title

  • Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence

• • Pubmed ID

  • 33466998

• • Reference

  • Molecules. 2021 Jan 16;26(2):444. doi: 10.3390/molecules26020444.

• • Author

  • Motoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu