General Information

    • DRAMP ID

    • DRAMP29018

    • Peptide Name

    • H-14

    • Source

    • Synthetic construct

    • Family

    • N/A

    • Gene

    • N/A

    • Sequence

    • IKLSKKTKKNLKKVLKGAIKGAIAVAKMV

    • Sequence Length

    • 29

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Anticancer

    • Target Organism

      • [Ref.30789695] Cancer cell lines: A549 (IC50 = 0.98 ± 0.11 μM), HCT116 (IC50 = 1.841 ± 0.34 μM), HepG2 (IC50 = 4.54 ± 0.25 μM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • α-helical (most likely)

    • Structure Description

    • No detailed structure description found.

    • Helical Wheel Diagram

    • DRAMP29018 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29018.

Physicochemical Information

    • Formula

    • C143H268N40O33S

    • Absent Amino Acids

    • CDEFHPQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3108.01

    • PI

    • 10.95

    • Basic Residues

    • 10

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +10

    • Boman Index

    • -1500

    • Hydrophobicity

    • 0.062

    • Aliphatic Index

    • 124.48

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP29018

DRAMP29018 chydropathy plot

Comments Information

    • Function

    • Anticancer activity.

    • Ref.30789695 does not include results of antimicrobial, hemolysis and other biological assays

Literature Information

  • ·Literature 1

    • Title

    • Improving Selectivity, Proteolytic Stability, and Antitumor Activity of Hymenochirin-1B: A Novel Glycosylated Staple Strategy

    • Reference

    • ACS Chem Biol. 2019 Mar 15;14(3):516-525. doi: 10.1021/acschembio.9b00046. Epub 2019 Mar 1.

    • Author

    • Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Honggang Hu, Xia Zhao