General Information
-
DRAMP ID
- DRAMP29037
-
Peptide Name
- [P5K,E6K]Hymenochirin-1B
-
Source
- Synthetic construct
-
Family
- N/A
-
Gene
- N/A
-
Sequence
- IKLSKKTKDNLKKVLKGAIKGAIAVAKMV
-
Sequence Length
- 29
-
UniProt Entry
- Notfound
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 μM), S. aureus ATCC 25923 (MIC = 3.1 μM), S.epidermidis RP62A (MIC = 1.6 μM), S.epidermidis RP62A/1 (MIC = 0.8 μM), C.albicans ATCC 90028 (MIC = 100 μM);
- Gram-negative bacteria: E.coli (MIC = 3.1 μM), A. baumannii (MIC = 3.1 μM), S. maltophilia (MIC = 1.6 μM), K. pneumoniae (MIC = 6.25 μM), P. aeruginosa (MIC = 12.5 μM), P.mirabilis (MIC > 100 μM).
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Hemolytic Activity
-
- [Ref.24172540] LC₅₀ = 137 ± 11 μM against freshly prepared human erythrocytes.
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- α-helical (most likely)
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Structure Description
- No structure indentification experiment and detailed structure description found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP29037.
Physicochemical Information
-
Formula
- C141H261N39O35S
Absent Amino Acids
- CEFHPQRWY
Common Amino Acids
- K
Mass
- 3094.92
PI
- 10.54
Basic Residues
- 9
Acidic Residues
- 1
Hydrophobic Residues
- 13
Net Charge
- +8
-
Boman Index
- -1817
Hydrophobicity
- 0.076
Aliphatic Index
- 124.48
Half Life
-
- Mammalian:20 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP29037
Comments Information
Function
- Antibacterial activity against Gram-positive and Gram-negative bacteria.
Literature Information
- ·Literature 1
-
Title
- An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties
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Pubmed ID
- 24172540
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Reference
- Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.
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Author
- Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon