General Information

    • DRAMP ID

    • DRAMP29042

    • Peptide Name

    • [E6k,D9k]Hymenochirin-1B

    • Source

    • Synthetic construct

    • Family

    • N/A

    • Gene

    • N/A

    • Sequence

    • IKLSPkTKkNLKKVLKGAIKGAIAVAKMV

    • Sequence Length

    • 29

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.24172540] Gram-positive bacteria: S. aureus ATCC 29213 (MIC = 3.1 μM), S. aureus ATCC 25923 (MIC = 1.6 μM), S.epidermidis RP62A (MIC = 0.8 μM), S.epidermidis RP62A/1 (MIC = 0.8 μM), C.albicans ATCC 90028 (MIC = 100 μM);
      • Gram-negative bacteria: E.coli (MIC = 3.1 μM), A. baumannii (MIC = 1.6 μM), S. maltophilia (MIC = 1.6 μM), K. pneumoniae (MIC = 3.1 μM), P. aeruginosa (MIC = 6.25 μM), P.mirabilis (MIC > 100 μM).

    • Hemolytic Activity

      • [Ref.24172540] LC₅₀ = 302 ± 21 μM against freshly prepared human erythrocytes.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • ①Introduction of D-amino acid(s). (Look at 'Stereochemistry')

    • Stereochemistry

    • Mixed (D-Lys6 and D-Lys9)

    • Structure

    • α-helical (most likely)

    • Structure Description

    • No structure indentification experiment and detailed structure description found

    • Helical Wheel Diagram

    • DRAMP29042 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29042.

Physicochemical Information

    • Formula

    • C142H263N39O33S

    • Absent Amino Acids

    • CDEFHQRWY

    • Common Amino Acids

    • K

    • Mass

    • 3076.95

    • PI

    • 10.9

    • Basic Residues

    • 9

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +9

    • Boman Index

    • -945

    • Hydrophobicity

    • 0.141

    • Aliphatic Index

    • 124.48

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP29042

DRAMP29042 chydropathy plot

Comments Information

    • Function

    • Antibacterial activity against Gram-positive and Gram-negative bacteria.

Literature Information

  • ·Literature 1

    • Title

    • An analog of the host-defense peptide hymenochirin-1B with potent broad-spectrum activity against multidrug-resistant bacteria and immunomodulatory properties

    • Reference

    • Peptides. 2013 Dec;50:153-9. doi: 10.1016/j.peptides.2013.10.015. Epub 2013 Oct 27.

    • Author

    • Milena Mechkarska, Manju Prajeep, Gordana D Radosavljevic, Ivan P Jovanovic, Amna Al Baloushi, Agnes Sonnevend, Miodrag L Lukic, J Michael Conlon