General Information

    • DRAMP ID

    • DRAMP29051

    • Peptide Name

    • Ctn[15-34] (C-terminal fragment of crotalicidin)

    • Source

    • Crotalus durissus terrificus (South American rattlesnake)

    • Family

    • Belongs to the cathelicidin family.

    • Gene

    • N/A

    • Sequence

    • KKRLKKIFKKPMVIGVTIPF

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antifungal

    • Target Organism

      • [Ref.33172206] Fungi: Candida albicans ATCC 90028 (MIC = 10 µM or 23.7 µg/mL), Candida albicans LABMIC 0125 (MIC = 10 µM or 23.7 µg/mL)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • Fungal plasma membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • α-helical

    • Structure Description

    • preserves helicity

    • Helical Wheel Diagram

    • DRAMP29051 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29051.

Physicochemical Information

    • Formula

    • C115H199N29O22S

    • Absent Amino Acids

    • ACDEHNQSWY

    • Common Amino Acids

    • K

    • Mass

    • 2372.09

    • PI

    • 11.43

    • Basic Residues

    • 7

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +7

    • Boman Index

    • -1378

    • Hydrophobicity

    • 0.05

    • Aliphatic Index

    • 107

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP29051

DRAMP29051 chydropathy plot

Comments Information

    • Comment

    • Ctn[15-34] showed to be an effective antifungal peptide, displaying antibiofilm activity and, importantly, interacting with and disrupting fungal plasma membrane. Function

Literature Information

  • ·Literature 1

    • Title

    • Antibiofilm Activity on Candida albicans and Mechanism of Action on Biomembrane Models of the Antimicrobial Peptide Ctn[15-34]

    • Reference

    • Int J Mol Sci. 2020 Nov 6;21(21):8339. doi: 10.3390/ijms21218339.

    • Author

    • Aguiar FLL, Santos NC, de Paula Cavalcante CS, Andreu D, Baptista GR, Gonçalves S.