General Information
-
DRAMP ID
- DRAMP29057
-
Peptide Name
- P5
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- N/A
-
Sequence
- RIVQRIKKWLLKWKKLGY
-
Sequence Length
- 18
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.31778756] Gram-negative bacteria: P. aeruginosa (MIC = 64 μg/mL, MBC = 128 μg/mL);
- Gram-positive bacteria: S. aureus (MIC = 16 µg/mL, MBC = 64 μg/mL)
-
Hemolytic Activity
-
- [Ref.31778756]P5 displayed less than 10% hemolysis in all the range tested (0-1024 μg/mL)
-
Cytotoxicity
-
- Not found
-
Binding Target
- Bacterial cytoplasmic membranes
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- α-helical
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29057.
Physicochemical Information
-
Formula
- C115H190N32O21
Absent Amino Acids
- ACDEFHMNPST
Common Amino Acids
- K
Mass
- 2356.98
PI
- 11.26
Basic Residues
- 7
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +7
-
Boman Index
- -2903
Hydrophobicity
- -0.606
Aliphatic Index
- 124.44
Half Life
-
- Mammalian:1 hour
- Yeast:2 min
- E.coli:2 min
Extinction Coefficient Cystines
- 12490
Absorbance 280nm
- 734.71
Polar Residues
- 2
DRAMP29057
Comments Information
Comment
- This new peptide could be good candidates for future drug development for anti-biofilm and anti-infective therapy.
Literature Information
- ·Literature 1
-
Title
- Antibacterial, anti-biofilm and in vivo activities of the antimicrobial peptides P5 and P6.2
-
Pubmed ID
- 31778756
-
Reference
- Microb Pathog. 2020 Feb;139:103886. doi: 10.1016/j.micpath.2019.103886. Epub 2019 Nov 25.
-
Author
- Martínez M, Polizzotto A, Flores N, Semorile L, Maffía PC