General Information

    • DRAMP ID

    • DRAMP29059

    • Peptide Name

    • temporin-GHaR

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • N/A

    • Sequence

    • FLQRIIGALGRLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • [Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 1.6μM / 1.6μM), B. subtilis(MIC / MBC = 12.5μM / 25μM), S. mutans(MIC / MBC = 3.1μM / 6.2μM), MRSA(MIC / MBC = 3.1μM / 3.1μM), MRSA-1(MIC /MBC = 3.1μM / 25μM), MRSA-2(MIC / MBC = 6.2μM / 12.5μM), MRSA-3(MIC / MBC = 3.1μM /6.2μM)
      • Gram-negative bacteria: E. coli(MIC / MBC = 6.2μM / 6.2μM), D31(MIC /MBC = 12.5μM / 25μM), P. aeruginosa(MIC / MBC = 6.2μM / 6.2μM), PAO1(MIC / MBC = 25μM / 50μM)
      • Fungi: C. albicans(MIC / MBC = 12.5μM / 50μM)

    • Hemolytic Activity

      • [Ref.33291521]HL50 = 48μM against human red blood cells (hRBCs)

    • Cytotoxicity

      • Not found

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • α-helical

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29059 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29059.

Physicochemical Information

    • Formula

    • C72H118N20O15

    • Absent Amino Acids

    • CDEHKMNPSTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1503.85

    • PI

    • 12

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • -113

    • Hydrophobicity

    • 1.115

    • Aliphatic Index

    • 157.69

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP29059

Comments Information

    • Comment

    • It showed potent antimicrobial activity with strong hemolytic toxicity

Literature Information

  • ·Literature 1

    • Title

    • Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis

    • Reference

    • Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.

    • Author

    • Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y