• • DRAMP ID

  • DRAMP29063

• • Peptide Name

  • GHaR9R (variant of temporin-GHaR)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • N/A

• • Sequence

  • FLQRIIGARGRLF

• • Sequence Length

  • 13

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Synthetic form

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • [Ref.33291521] Gram-positive bacteria: S. aureus(MIC / MBC = 6.2μM / 12.5μM), B. subtilis(MIC / MBC > 50μM / 50μM), S. mutans(MIC / MBC > 50μM / 50μM), MRSA(MIC / MBC > 50μM / 50μM), MRSA-1(MIC / MBC > 50μM / 50μM), MRSA-2(MIC / MBC > 50μM / 50μM), MRSA-3(MIC / MBC > 50μM / 50μM)
    • Gram-negative bacteria: E. coli(MIC / MBC > 50μM / 50μM), D31(MIC / MBC > 50μM / 50μM), P. aeruginosa(MIC / MBC > 50μM / 50μM), PAO1(MIC / MBC > 50μM / 50μM)
    • Fungi: C. albicans(MIC / MBC > 50μM / 50μM)

• • Hemolytic Activity

  • • [Ref.33291521]GHaR9R didn t show hemolytic toxicity even when the concentration was raised up to 200 μM.

• • Cytotoxicity

  • • Not found

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • the α-helical structure of GHaR9R was destroyed

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP29063.

DRAMP29063

• • Comment

  • The antimicorbial activity of GHaR9R is bad comparing to other temporin-GHaR modified peptides.

• ·Literature 1

• • Title

  • Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis

• • Pubmed ID

  • 33291521

• • Reference

  • Molecules. 2020 Dec 4;25(23):5724. doi: 10.3390/molecules25235724.

• • Author

  • Wei H, Xie Z, Tan X, Guo R, Song Y, Xie X, Wang R, Li L, Wang M, Zhang Y