General Information
-
DRAMP ID
- DRAMP29085
-
Peptide Name
- B-GH23-1
-
Source
- Hylarana guentheri
-
Family
- Not found
-
Gene
- N/A
-
Sequence
- GLVTDTLKGAAKTVAAELLRKAH
-
Sequence Length
- 23
-
UniProt Entry
- No entry found
-
Protein Existence
- Synthetic form
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-
-
Target Organism
-
- [Ref.31549575] Gram-positive bacteria: Staphylococcus aureus (MIC = 32-64 μM), Streptococcus mutans(MIC > 100 μM);
- Gram-negative bacteria: Escherichia coli (MIC > 100 μM), Pseudomonas aeruginosa(MIC > 100 μM);
- Yeast: Canidia albican (MIC > 100 μM)
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not found
-
Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29085.
Physicochemical Information
-
Formula
- C104H183N31O31
Absent Amino Acids
- CFIMNPQSWY
Common Amino Acids
- A
Mass
- 2363.79
PI
- 9.7
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 11
Net Charge
- +3
-
Boman Index
- -2078
Hydrophobicity
- 0.144
Aliphatic Index
- 114.78
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 5
DRAMP29085
Comments Information
Comment
- B-GH23-1 had slight antibacterial activity on S.aureus
Literature Information
- ·Literature 1
-
Title
- Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus
-
Pubmed ID
- 31549575
-
Reference
- Biosci Biotechnol Biochem. 2020 Jan;84(1):143-153. doi: 10.1080/09168451.2019.1670045. Epub 2019 Sep 24.
-
Author
- Hengren Zhong, Zhipeng Xie, Shuxia Zhang, Hanqi Wei, Yanting Song, Yingxia Zhang, Manchuriga Wang