General Information

    • DRAMP ID

    • DRAMP29086

    • Peptide Name

    • B-GH23-2

    • Source

    • Hylarana guentheri

    • Family

    • Not found

    • Gene

    • N/A

    • Sequence

    • GVITDALKGAAKTVAAELPRKAH

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic form

Activity Information

    • Biological Activity

    • Non-antimicrobial

    • Target Organism

      • [Ref.31549575] Gram-positive bacteria: Staphylococcus aureus (MIC > 100 μM), Streptococcus mutans(MIC > 100 μM);
      • Gram-negative bacteria: Escherichia coli (MIC > 100 μM), Pseudomonas aeruginosa(MIC > 100 μM);
      • Yeast: Canidia albican (MIC > 100 μM)

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not found

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29086 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29086.

Physicochemical Information

    • Formula

    • C102H177N31O30

    • Absent Amino Acids

    • CFMNQSWY

    • Common Amino Acids

    • A

    • Mass

    • 2317.72

    • PI

    • 9.7

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +3

    • Boman Index

    • -2132

    • Hydrophobicity

    • 0.048

    • Aliphatic Index

    • 102.17

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP29086

DRAMP29086 chydropathy plot

Comments Information

    • Comment

    • B-GH23-2 did not have any antimicrobial activity.

Literature Information

  • ·Literature 1

    • Title

    • Brevinin-GR23 from frog Hylarana guentheri with antimicrobial and antibiofilm activities against Staphylococcus aureus

    • Reference

    • Biosci Biotechnol Biochem. 2020 Jan;84(1):143-153. doi: 10.1080/09168451.2019.1670045. Epub 2019 Sep 24.

    • Author

    • Hengren Zhong, Zhipeng Xie, Shuxia Zhang, Hanqi Wei, Yanting Song, Yingxia Zhang, Manchuriga Wang