• • DRAMP ID

  • DRAMP29105

• • Peptide Name

  • c Mastoparan-C(cMP-C)

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • N/A

• • Sequence

  • CLNLKALLAVAKKILC

• • Sequence Length

  • 16

• • UniProt Entry

  • P01516

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-, Anti-cancer,Antifungal

• • Target Organism

  • • [Ref.29904274]Gram-positive bacteria:Staphylococcus aureus NCTC 10788(MIC=32 µM); Staphylococcus aureus NCTC 10788(MBC=64 µM); Staphylococcus aureus ATCC 12493(MRSA,MIC=128 µM); Staphylococcus aureus ATCC 12493(MRSA,MBC=128 µM); Enterococcus faecalis NCTC 12697(MIC=128 µM); Enterococcus faecalis NCTC 12697(MBC=128 µM);
    • Gram-negative bacteria:Escherichia coli NCTC 10418(MIC=32 µM); Escherichia coli NCTC 10418(MBC=128 µM); Pseudomonas aeruginosa ATCC 27853(MIC=32 µM); Pseudomonas aeruginosa ATCC 27853(MBC>512 µM);
    • Fungi:Candida albicans NCTC 1467(MIC=32 µM); Candida albicans NCTC 1467(MBC=128 µM);
    • Cancer:Human squamous lung carcinoma NCI-H157(IC50=7.02 µM);Human breast adenocarcinoma MDA-MB-435S(IC50=13.87 µM);Human prostate adenocarcinoma PC-3(IC50=13.87 µM);Human glioblastoma U251-MG(IC50=8.56 µM); Human breast adenocarcinoma MCF-7(IC50=13.66 µM).

• • Hemolytic Activity

  • • [Ref.29904274]50% hemolysis against horse erythrocytes at 9.19 µM.

• • Cytotoxicity

  • • [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=39.53 µM).

• • Binding Target

  • liposomes

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Disulfide bond (Cys1-Cys16)

• • Stereochemistry

  • L

• • Structure

  • Alpha helix,random coil

• • Structure Description

  • 76% α-helix was determined from the circular dichroism spectra recorded in 50% TFE/10mM NH4AC solution,28% of the secondary structure retained an α-helical domain in an aqueous environment.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP29105.

DRAMP29105

• • Function

  • Antibacterial activity against Gram-positive bacteria and Gram-negative bacteria.

• ·Literature 1

• • Title

  • Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering.

• • Pubmed ID

  • 29904274

• • Reference

  • Int J Biol Sci. 2018 Apr 25;14(6):599-607.

• • Author

  • Chen X, Zhang L, Wu Y, Wang L, Ma C, Xi X, Bininda-Emonds ORP, Shaw C, Chen T, Zhou M.