General Information
-
DRAMP ID
- DRAMP29127
-
Peptide Name
- Mastoparan-C (1-11)
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- N/A
-
Sequence
- LNLKALLAVAK
-
Sequence Length
- 11
-
UniProt Entry
- P01516
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial,Anti-Gram+, Anti-Gram-
-
Target Organism
-
- [Ref.33285267]Gram-positive bacteria:Staphylococcus aureus ATCC 25923(MIC>128 µM); Bacillus subtilis ATCC 23857(MIC>128 µM);
- Gram-negative bacteria:Escherichia coli ATCC 25922(MIC>128 µM); Pseudomonas aeruginosa ATCC 9027(MIC>128 µM); Klebsiella pneumoniae ATCC 700603(MIC>128 µM).
-
Hemolytic Activity
-
- [Ref.33285267]0% hemolysis against mouse erythrocytes at 256 µM.
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- liposomes
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix,random coil
-
Structure Description
- The CD spectra in water adopts a random-coil conformation,24.68% α-helix was determined in 50% TFE.
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29127.
Physicochemical Information
-
Formula
- C54H100N14O13
Absent Amino Acids
- CDEFGHIMPQRSTWY
Common Amino Acids
- L
Mass
- 1153.47
PI
- 10
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +2
-
Boman Index
- 1141
Hydrophobicity
- 1.227
Aliphatic Index
- 195.45
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 1
DRAMP29127
Comments Information
Function
- when combined with gentamicin, rifampin, and polymyxin B, it demonstrated synergistic or additive activity against E. coli ATCC 25922 and P. aeruginosa ATCC 9027.
Literature Information
- ·Literature 1
-
Title
- Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria.
-
Pubmed ID
- 33285267
-
Reference
- Eur J Pharm Sci. 2021 Mar 1;158:105665.
-
Author
- Zhu N, Zhong C, Liu T, Zhu Y, Gou S, Bao H, Yao J, Ni J.