• DRAMP ID

    • DRAMP29185
    • Peptide Name

    • IPB07(SARS-CoV-2-S (1179-1211))
    • Source

    • Synthetic construct
    • Family

    • Belongs to the betacoronaviruses spike protein family.
    • Gene

    • S
    • Sequence

    • IQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
    • Sequence Length

    • 33
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.32376627]Virus:
      • SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50=0.017 ± 0.001 µM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50=0.993 ± 0.08 µM);
      • SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC=1.037 ± 0.836 µM);
      • Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 µM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • liposomes
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Chol
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Alpha helix
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29185 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29185.
    • Formula

    • C175H288N46O57
    • Absent Amino Acids

    • CFHMPTW
    • Common Amino Acids

    • EL
    • Mass

    • 3948.49
    • PI

    • 4.77
    • Basic Residues

    • 5
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 11
    • Net Charge

    • -2
    • Boman Index

    • -7776
    • Hydrophobicity

    • -0.8
    • Aliphatic Index

    • 118.18
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 2980
    • Absorbance 280nm

    • 93.13
    • Polar Residues

    • 7

DRAMP29185

DRAMP29185 chydropathy plot
    • Mechanism of action

    • The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently.
  • ·Literature 1
    • Title

    • Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity.
    • Reference

    • J Virol. 2020 Jul 1;94(14):e00635-20.
    • Author

    • Zhu Y, Yu D, Yan H, Chong H, He Y.