General Information
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral(SARS-CoV-2)
-
Target Organism
-
- [Ref.32376627]Virus:
- SARS-CoV-2:ihibition of cell-cell fusion in 293T/ACE2 cells(IC50>5 µM),inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>25 µM);
- SARS-CoV:inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC>25 µM);
- Vesicular Stomatitis Virus (VSV):inhibition of Pseudovirus (PsV) infection in 293T/ACE2 cells(IC50>50 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- liposomes
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Chol
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29187.
Physicochemical Information
-
Formula
- C124H216N36O41
Absent Amino Acids
- CFGHMPTWY
Common Amino Acids
- N
Mass
- 2867.3
PI
- 5.98
Basic Residues
- 4
Acidic Residues
- 4
Hydrophobic Residues
- 10
Net Charge
- 0
-
Boman Index
- -5617
Hydrophobicity
- -0.4
Aliphatic Index
- 132.4
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP29187
Comments Information
Mechanism of action
- The peptide was designed based on HR2 sequence lipopeptide fusion inhibitor,which showed highly potent activities in inhibiting SARS-CoV-2 S protein-mediated cell-cell fusion and pseudovirus transduction. It can also inhibit the SARS-CoV pseudovirus efficiently.
Literature Information
- ·Literature 1
-
Title
- Design of Potent Membrane Fusion Inhibitors against SARS-CoV-2, an Emerging Coronavirus with High Fusogenic Activity.
-
Pubmed ID
- 32376627
-
Reference
- J Virol. 2020 Jul 1;94(14):e00635-20.
-
Author
- Zhu Y, Yu D, Yan H, Chong H, He Y.