• DRAMP ID

    • DRAMP29192
    • Peptide Name

    • ACE2 (27-42)(SAP1)
    • Source

    • Synthetic construct
    • Family

    • Belongs to the peptidase M2 family.
    • Gene

    • ACE2
    • Sequence

    • TFLDKFNHEAEDLFYQ
    • Sequence Length

    • 16
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.33356169]Virus:
      • SARS-CoV-2:Inhibition of infection in 293T/ACE2 cells(IC50=2.39±0.20 mM);Inhibition of infection in 293T/ACE2/GFP cells(IC50=3 mM);
      • SARS-CoV:Inhibition of infection in 293T/ACE2 cells(80% inhibition at 3 mM);
      • Vesicular Stomatitis Virus (VSV):No nhibition of infection in 293T/ACE2 cells up to 3 mM;
      • HCoV-NL63:Inhibition of cytopathic effect in LLC-MK2 cells(30% Inhibition at 3 mM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29192 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29192.
    • Formula

    • C94H129N21O29
    • Absent Amino Acids

    • CGIMPRSVW
    • Common Amino Acids

    • F
    • Mass

    • 2017.18
    • PI

    • 4.31
    • Basic Residues

    • 2
    • Acidic Residues

    • 4
    • Hydrophobic Residues

    • 6
    • Net Charge

    • -2
    • Boman Index

    • -3557
    • Hydrophobicity

    • -0.769
    • Aliphatic Index

    • 55
    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 99.33
    • Polar Residues

    • 3

DRAMP29192

    • Mechanism of action

    • Inhibiting SARS-CoV-2 infection by disrupting the Spike-ACE2 interaction interface with peptide-based inhibitors.
  • ·Literature 1
    • Title

    • Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.
    • Reference

    • Bioconjug Chem. 2021 Jan 20;32(1):215-223.
    • Author

    • Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A.