• DRAMP ID

    • DRAMP29201
    • Peptide Name

    • SARS-CoV-2 HR1P
    • Source

    • Synthetic construct
    • Family

    • Belongs to the betacoronaviruses spike protein family.
    • Gene

    • S
    • Sequence

    • ANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQ
    • Sequence Length

    • 42
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.32047258]Virus:SARS-CoV-2(No inhibition of cell-cell fusion up to 40 µM in Huh-7 cells,No inhibition of infection up to 40 µM in 293T/ACE2 cells)
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29201 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29201.
    • Formula

    • C187H314N56O65
    • Absent Amino Acids

    • CEHMPRWY
    • Common Amino Acids

    • AQ
    • Mass

    • 4386.89
    • PI

    • 8.54
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 17
    • Net Charge

    • +1
    • Boman Index

    • -6039
    • Hydrophobicity

    • -0.219
    • Aliphatic Index

    • 100
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 14

DRAMP29201

DRAMP29201 chydropathy plot
    • Mechanism of action

    • The peptide acted as a fusion inhibitor which against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection.
  • ·Literature 1
    • Title

    • Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein.
    • Reference

    • Cell Mol Immunol. 2020 Jul;17(7):765-767.
    • Author

    • Xia S, Zhu Y, Liu M, Lan Q, Xu W, Wu Y, Ying T, Liu S, Shi Z, Jiang S, Lu L.