General Information

    • DRAMP ID

    • DRAMP29207

    • Peptide Name

    • P8

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SALEEQLKTFLDKFMHELEDLLYQLAL

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)

    • Target Organism

      • [Ref.33580154]Virus:SARS-CoV-2:91% inhibition of replication in Vero-E6 cells at 10 μM;inhibition of replication in Calu-3 cells(IC50=46 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.33580154]The peptide proved to be devoid of cell toxicity on Vero-E6 and Calu-3 cells.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29207 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29207.

Physicochemical Information

    • Formula

    • C149H233N33O45S

    • Absent Amino Acids

    • CGINPRVW

    • Common Amino Acids

    • L

    • Mass

    • 3238.74

    • PI

    • 4.35

    • Basic Residues

    • 3

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 12

    • Net Charge

    • -3

    • Boman Index

    • -2634

    • Hydrophobicity

    • -0.011

    • Aliphatic Index

    • 122.96

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 57.31

    • Polar Residues

    • 3

DRAMP29207

DRAMP29207 chydropathy plot

Comments Information

    • Mechanism of action

    • The peptide was designed mimicking the N-terminal helix of hACE2 protein,which could prevent the SARS-CoV-2 from infecting human cells, blocking the interaction between hACE2 and the virus spike protein.

Literature Information

  • ·Literature 1

    • Title

    • Human ACE2 peptide-mimics block SARS-CoV-2 pulmonary cells infection.

    • Reference

    • Commun Biol. 2021 Feb 12;4(1):197.

    • Author

    • Karoyan P, Vieillard V, Gómez-Morales L, Odile E, Guihot A, Luyt CE, Denis A, Grondin P, Lequin O.