• DRAMP ID

    • DRAMP29217
    • Peptide Name

    • IBP22
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
    • Sequence Length

    • 37
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=6.23 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=179.95 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=86.33 nM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • C18(stearic acid)
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29217 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29217.
    • Formula

    • C192H317N51O63
    • Absent Amino Acids

    • CFHMPTW
    • Common Amino Acids

    • EL
    • Mass

    • 4347.93
    • PI

    • 4.77
    • Basic Residues

    • 5
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 13
    • Net Charge

    • -2
    • Boman Index

    • -7972
    • Hydrophobicity

    • -0.603
    • Aliphatic Index

    • 121.08
    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 2980
    • Absorbance 280nm

    • 82.78
    • Polar Residues

    • 9

DRAMP29217

DRAMP29217 chydropathy plot
    • Mechanism of action

    • Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived.
  • ·Literature 1
    • Title

    • Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants.
    • Reference

    • Emerg Microbes Infect. 2021 Dec;10(1):1227-1240.
    • Author

    • Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y.