General Information
-
DRAMP ID
- DRAMP29221
-
Peptide Name
- IBP26
-
Source
- Synthetic construct
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- SVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIK
-
Sequence Length
- 37
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral(SARS-CoV-2)
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Target Organism
-
- [Ref.34057039]Virus:SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.26 nM);inhibition of pseudovirus infections in 293T/ACE2 cells(IC50=3.05 nM);inhibition of pseudovirus infections in Huh-7 cells(IC50=1.82 nM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- PEG6-K(Chol)
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29221.
Physicochemical Information
-
Formula
- C192H317N51O63
Absent Amino Acids
- CFHMPTW
Common Amino Acids
- EL
Mass
- 4347.93
PI
- 4.77
Basic Residues
- 5
Acidic Residues
- 7
Hydrophobic Residues
- 13
Net Charge
- -2
-
Boman Index
- -7972
Hydrophobicity
- -0.603
Aliphatic Index
- 121.08
Half Life
-
- Mammalian:1.9 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 82.78
Polar Residues
- 9
DRAMP29221
Comments Information
Mechanism of action
- Peptides derived from HR2 sequences of viral fusion proteins, including the S protein of emerging CoVs, can competitively bind to the HR1 domain and block the formation of the viral 6-HB core, thereby inhibiting infection of the virus from which they were derived.
Literature Information
- ·Literature 1
-
Title
- Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants.
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Pubmed ID
- 34057039
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Reference
- Emerg Microbes Infect. 2021 Dec;10(1):1227-1240.
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Author
- Yu D, Zhu Y, Jiao T, Wu T, Xiao X, Qin B, Chong H, Lei X, Ren L, Cui S, Wang J, He Y.