• DRAMP ID

    • DRAMP29226
    • Peptide Name

    • IBP02V4
    • Source

    • Synthetic construct
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • ELSGINASVVNLQKEIDRLNEVAKNLNESLIDLQEL
    • Sequence Length

    • 36
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antiviral(SARS-CoV-2)
    • Target Organism

      • [Ref.34344868]Virus:
      • SARS-CoV-2:inhibition of SARS-CoV-2 S protein-mediated cell-cell fusion(IC50=0.3±0.02 nM);inhibition of SARS-CoV-2 pseudovirus infection in 293T/ACE2 cells(IC50=18.6 nM);inhibition of SARS-CoV-2 pseudovirus infection in Huh-7 cells(IC50=15.2 nM);
      • SARS-CoV-2 D614G:inhibition of S protein-mediated cell-cell fusion(IC50=0.1±0.02 nM);inhibition of pseudovirus infection in 293T/ACE2 cells(IC50=29.2 nM);inhibition of pseudovirus infection in Huh-7 cells(IC50=26.3 nM);
      • SARS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=63±1.7 nM);
      • MERS-CoV:inhibition of pseudovirus infection in Huh-7 cells(IC50=22.4±2.2 nM);
      • HCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells(IC50=66.3±3.1 nM);
      • HCoV-229E:inhibition of pseudovirus infection in Huh-7 cells(IC50=502±24.2 nM).
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • [Ref.34344868]No significant cytotoxicity in both 293T/ACE2 and Huh-7 cells at a concentration of 10 μM.
    • Binding Target

    • liposomes
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • PEG8-K(Chol)
    • Nonterminal Modifications and Unusual Amino Acids

    • None
    • Stereochemistry

    • L
    • Structure

    • 59% α-helicity in phosphate-buffered saline (PBS; pH 7.2) with a final concentration of 10 μM and incubated at 37°C
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP29226 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP29226.
    • Formula

    • C173H294N48O61
    • Absent Amino Acids

    • CFHMPTWY
    • Common Amino Acids

    • L
    • Mass

    • 4022.52
    • PI

    • 4.25
    • Basic Residues

    • 3
    • Acidic Residues

    • 7
    • Hydrophobic Residues

    • 15
    • Net Charge

    • -4
    • Boman Index

    • -6611
    • Hydrophobicity

    • -0.217
    • Aliphatic Index

    • 138.06
    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 9

DRAMP29226

DRAMP29226 chydropathy plot
    • The peptide is a fusion inhibitor against SARS-CoV-2.

  • ·Literature 1
    • Title

    • SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses.
    • Reference

    • Signal Transduct Target Ther. 2021 Aug 3;6(1):294.
    • Author

    • Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y.