• • DRAMP ID

  • DRAMP29233

• • Peptide Name

  • Alisporivir, Debio-025

• • Source

  • Synthetic construct

• • Family

  • Not found

• • Gene

  • Not found

• • Sequence

  • XxXVXAaXXXX

• • Sequence Length

  • 11

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antiviral(SARS-CoV-2)

• • Target Organism

  • • [Ref.32376613]Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells(EC50=0.46±0.04 µM,E90=3.10±1.40 μM).
    • [Ref.32568027]Virus:
    • SARS-CoV-2:Inhibition of infection in Vero E6 cells(EC50=4.9±1.3 µM);
    • SARS-CoV:Inhibition of infection in Vero E6 cells(EC50=4.3±1.0 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • [Ref.32376613]Vero E6 cells:CC50>20µM.

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Cyclic

• • N-terminal Modification

  • No specific N-terminal

• • C-terminal Modification

  • No specific C-terminal

• • Nonterminal Modifications and Unusual Amino Acids

  • The 'X' at position 1 is alpha-aminobutyric acid,position 2 is N-methylalanine,the 'V' at position 3 is N-methylalanine,the 'X' at position 5,8,9 are N-methylleucine,the 'X' at position 10 is N-methylvaline and position 11 is N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl

• • Stereochemistry

  • Mixed(D-Ala7,D-meth-Ala2)

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP29233.

DRAMP29233

• • Comment

  • No comments found on DRAMP database

• ·Literature 1

• • Title

  • Inhibition of SARS-CoV-2 Infection by the Cyclophilin Inhibitor Alisporivir (Debio 025).

• • Pubmed ID

  • 32376613

• • Reference

  • Antimicrob Agents Chemother. 2020 Jun 23;64(7):e00876-20.

• • Author

  • Softic L, Brillet R, Berry F, Ahnou N, Nevers Q, Morin-Dewaele M, Hamadat S, Bruscella P, Fourati S, Pawlotsky JM, Ahmed-Belkacem A.

• ·Literature 2

• • Title

  • SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology.

• • Pubmed ID

  • 32568027

• • Reference

  • J Gen Virol. 2020 Sep;101(9):925-940.

• • Author

  • Ogando NS, Dalebout TJ, Zevenhoven-Dobbe JC, Limpens RWAL, van der Meer Y, Caly L, Druce J, de Vries JJC, Kikkert M, Bárcena M, Sidorov I, Snijder EJ.