General Information

    • DRAMP ID

    • DRAMP29243

    • Peptide Name

    • Peptide 4(lactoferrin 441–454)

    • Source

    • Synthetic construct

    • Family

    • Belongs to the transferrin family

    • Gene

    • LTF

    • Sequence

    • KANEGLTWNSLKDK

    • Sequence Length

    • 14

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral

    • Target Organism

      • [Ref.28878220]Virus:A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=1± 0.15 pM);
      • A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells(EC50=50.000 ± 250 pM);
      • A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells(EC50=1.000 ± 360 pM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • hemagglutinin (HA)

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29243 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP29243.

Physicochemical Information

    • Formula

    • C70H114N20O23

    • Absent Amino Acids

    • CFHIMPQRVY

    • Common Amino Acids

    • K

    • Mass

    • 1603.8

    • PI

    • 8.5

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +1

    • Boman Index

    • -3651

    • Hydrophobicity

    • -1.364

    • Aliphatic Index

    • 62.86

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 423.08

    • Polar Residues

    • 5

DRAMP29243

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors.

    • Reference

    • Sci Rep. 2017 Sep 6;7(1):10593.

    • Author

    • Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P.