General Information

    • DRAMP ID

    • DRAMP29251

    • Peptide Name

    • Ac-SAHS-NH2

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • SAHS

    • Sequence Length

    • 4

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial,Antiviral

    • Target Organism

      • [Ref.34681184]Virus:A/Roma-ISS/02/08 H1N1:inhibition of virus replication in MDCK cells(EC50=5.77 ± 0.01 × 10−7 μM);
      • A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells(EC50=4.3 ± 0.3 × 10−10 μM);
      • A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells(EC50=9.36 ± 0.1 × 10−7 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • hemagglutinin (HA)

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29251 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29251.

Physicochemical Information

    • Formula

    • C15H24N6O7

    • Absent Amino Acids

    • CDEFGIKLMNPQRTVWY

    • Common Amino Acids

    • S

    • Mass

    • 400.39

    • PI

    • 6.46

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +1

    • Boman Index

    • -965

    • Hydrophobicity

    • -0.75

    • Aliphatic Index

    • 25

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP29251

Comments Information

    • Function

    • Antiviral activity against Influenza virus.

Literature Information

  • ·Literature 1

    • Title

    • Discovery of a Novel Tetrapeptide against Influenza A Virus: Rational Design, Synthesis, Bioactivity Evaluation and Computational Studies.

    • Reference

    • Pharmaceuticals (Basel). 2021 Sep 23;14(10):959. 

    • Author

    • Scala MC, Agamennone M, Pietrantoni A, Di Sarno V, Bertamino A, Superti F, Campiglia P, Sala M.